Mutated genes, pathways and processes in tumours

被引：31

作者：

Baudot, Anais

de la Torre, Victor ^{[1
]}

Valencia, Alfonso ^{[1
]}

机构：

[1] Spanish Natl Canc Res Ctr CNIO, Struct Biol & Biocomp Programme, Natl Bioinformat Inst Unit, E-28029 Madrid, Spain

来源：

EMBO REPORTS | 2010年 / 11卷 / 10期

关键词：

cancer-mutated genes; large-scale resequencing; oncogenomics; pathways; systems biology; ACUTE MYELOID-LEUKEMIA; SOMATIC MUTATIONS; COLORECTAL CANCERS; HUMAN BREAST; TYROSINE KINOME; LUNG-CANCER; GENOME; GLIOBLASTOMA; CARCINOMA; KNOWLEDGEBASE;

D O I：

10.1038/embor.2010.133

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Integration of the many available sources of cancer gene information-such as large-scale tumour-resequencing studies-identifies the 'usual suspect' genes, mutated in many tumour types, as well as different sets of mutated genes according to the specific tumour type. Scaling-up the analysis reveals that this large collection of mutated genes cluster into a smaller number of signalling pathways and processes. From this, we draw a map of the altered processes, and their combinations, in more than 10 tumours types. Literature searches identify pathways and processes that are covered sparsely in the literature, and invite the proposal of new hypotheses to investigate cancer initiation and progression.

引用

页码：805 / 810

页数：6

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