Enantioselective synthesis of complementary double-helical molecules that catalyze asymmetric reaction

被引:104
作者
Hasegawa, Takashi
Furusho, Yoshio
Katagiri, Hiroshi
Yashima, Eiji
机构
[1] Japan Sci & Technol Agcy, ERATO, Yashima Super Struct Helix Project, Moriyama Ku, Nagoya, Aichi 4630003, Japan
[2] Nagoya Univ, Grad Sch Engn, Chikusa Ku, Nagoya, Aichi 4648603, Japan
关键词
amidines; asymmetric synthesis; helical structures; platinum; salt bridges;
D O I
10.1002/anie.200701735
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Two twisted: Optically active double helices were synthesized through a twist-sense bias induced by a chiral phosphine ligand on one of the complementary metallostrands followed by a ligand-exchange reaction with an achiral bidentate ligand, which replaces the chiral ligand, to bridge the two strands. Furthermore, the double helices can efficiently catalyze asymmetric cyclopropanation. (Figure Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码:5885 / 5888
页数:4
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