Synthesis of 2′-O,3′-O bicyclic adenosine analogues using ring closing metathesis

被引：23

作者：

Busca, P ^{[1
]}

Etheve-Quelquejeu, M ^{[1
]}

Valéry, JM ^{[1
]}

机构：

[1] Univ Paris 06, CNRS, UMR Struct & Fonct Mol Bioact 7613, Equipe Chim Glucides, F-75252 Paris 05, France

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 51期

关键词：

ligases; nucleosides; ring closure metathesis;

D O I：

10.1016/j.tetlet.2003.10.059

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 2'-O,3'-O bicyclic adenosine derivatives is presented as the first examples of a new family of 13-membered ring bicyclic nucleoside analogues. Cyclisation was achieved through ring closing metathesis (RCM) on a diene intermediate using Grubbs' catalyst. The Z and E isomers were purified and characterised. (C) 2003 Elsevier Ltd. All rights reserved.

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页码：9131 / 9134

页数：4

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