Synthesis and antiviral evaluation of some 5-N-arylaminomethyl-2-glycosylsulphanyl-1,3,4-oxadiazoles and their analogs against hepatitis A and herpes simplex viruses

被引：55

作者：

El-Sayed, Wael A. ^{[2
]}

Fathi, Nahed M. ^{[2
]}

Gad, W. A. ^{[2
]}

El-Ashry, El Sayed H. ^{[1
,3
]}

机构：

[1] Univ Alexandria, Fac Sci, Dept Chem, Alexandria, Egypt

[2] Natl Res Ctr, Photochem Dept, Cairo, Egypt

[3] Univ Karachi, Int Ctr Chem & Biol Sci, Karachi, Pakistan

来源：

JOURNAL OF CARBOHYDRATE CHEMISTRY | 2008年 / 27卷 / 06期

关键词：

thioglycosides; oxadiazole; S-functionalized-oxadiazole; glycinoyl hydrazine; antiviral activity; herpes simplex virus type 1 (HSV-1); hepatitis A virus (HAV);

D O I：

10.1080/07328300802262778

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

N-Arylaminomethyl-3H-1,3,4-oxadiazole-2-thiones 2a,b were prepared from the corresponding N-arylglycinoylhydrazides. A number of their thioglycoside derivatives 4-7a-c and S-functionalized analogs 8-11a,b were synthesized by the reaction with different acetobromosugars and acyclic hydroxyalkylating agents. The antiviral activity of a number of the synthesized compounds against herpes simplex virus type 1 (HSV-1) and hepatitis A virus (HAV) was evaluated. Compounds 5a and 5b showed promising results against HAV.

引用

页码：357 / 372

页数：16

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