Tales from the crypt[ic] sites of the extracellular matrix

被引：153

作者：

Schenk, S ^{[1
]}

Quaranta, V ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA

来源：

TRENDS IN CELL BIOLOGY | 2003年 / 13卷 / 07期

关键词：

D O I：

10.1016/S0962-8924(03)00129-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Proteolytic cleavage of extracellular matrix (ECM) proteins by matrix metalloproteinases and/or conformational changes unmask 'cryptic' sites and liberate fragments with biological activities that are not observed in the intact molecule. Cryptic sites and fragments of ECM macromolecules have been implicated in many events governed by cell-ECM interactions, such as migration, invasion, adhesion and differentiation. The unmasking of cryptic sites is a tightly controlled process, reflecting the importance of cryptic ECM functions. This review summarizes and evaluates the current developments regarding cryptic regulatory ECM signals found as ECM-tethered protein epitopes or fragments.

引用

页码：366 / 375

页数：10

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