Diastereo- and enantioselective synthesis of N,O-nucleosides

被引：37

作者：

Chiacchio, U

Corsaro, A

Iannazzo, D

Piperno, A

Pistarà, V

Rescifina, A

Romeo, R

Sindona, G

Romeo, G

机构：

[1] Univ Catania, Dipartimento Sci Chim, I-95125 Catania, Italy

[2] Univ Messina, Dipartimento Farmacochim, I-98168 Messina, Italy

[3] Univ Calabria, Dipartimento Chim, I-87036 Cosenza, Italy

来源：

TETRAHEDRON-ASYMMETRY | 2003年 / 14卷 / 18期

关键词：

D O I：

10.1016/S0957-4166(03)00499-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The diastereo- and enantioselective synthesis of alpha- and beta-3'-hydroxymethyl-N,O-nucleosides is described, based on the 1,3-dipolar cycloaddition of a N-glycosyl nitrone. Two approaches have been evaluated: the one-step procedure, which uses vinyl nucleobases, showed a better stereoselectivity towards beta-nucleosides. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：2717 / 2723

页数：7

共 29 条

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[2]

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[3]

2-K

[4]

Chiacchio U, 2002, EUR J ORG CHEM, V2002, P1206