Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer

被引：1340

作者：

Siegel, PM ^{[1
]}

Massagué, J ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, Canc Biol & Genet Program, New York, NY 10021 USA

来源：

NATURE REVIEWS CANCER | 2003年 / 3卷 / 11期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrc1208

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The cytostatic and apoptotic functions of transforming growth factor-beta (TGF-beta) help restrain the growth of mammalian tissues; loss of these effects leads to hyperproliferative disorders and is common in cancer. However, tumour cells that are relieved from TGF-beta growth constraints might then overproduce this cytokine to create a local immunosuppressive environment that fosters tumour growth and exacerbates the invasive and metastatic behaviour of the tumour cells themselves. For these reasons, there is a growing interest in understanding and therapeutically targeting TGF-beta-mediated processes in cancer progression.

引用

收藏

页码：807 / 820

页数：14

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