Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer

被引：1340

作者：

Siegel, PM ^{[1
]}

Massagué, J ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, Canc Biol & Genet Program, New York, NY 10021 USA

来源：

NATURE REVIEWS CANCER | 2003年 / 3卷 / 11期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrc1208

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The cytostatic and apoptotic functions of transforming growth factor-beta (TGF-beta) help restrain the growth of mammalian tissues; loss of these effects leads to hyperproliferative disorders and is common in cancer. However, tumour cells that are relieved from TGF-beta growth constraints might then overproduce this cytokine to create a local immunosuppressive environment that fosters tumour growth and exacerbates the invasive and metastatic behaviour of the tumour cells themselves. For these reasons, there is a growing interest in understanding and therapeutically targeting TGF-beta-mediated processes in cancer progression.

引用

收藏

页码：807 / 820

页数：14

相关论文

共 177 条

[141]

Stearns ME, 1999, CLIN CANCER RES, V5, P711

[142] Overexpression of the TGF beta-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cells [J].

Tachibana, I ;

Imoto, M ;

Adjei, PN ;

Gores, GJ ;

Subramaniam, M ;

Spelsberg, TC ;

Urrutia, R .

JOURNAL OF CLINICAL INVESTIGATION, 1997, 99 (10) :2365-2374

[143] Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-β signaling by Smad7 [J].

Tajima, Y ;

Goto, K ;

Yoshida, M ;

Shinomiya, K ;

Sekimoto, T ;

Yoneda, Y ;

Miyazono, K ;

Imamura, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (12) :10716-10721

[144]

Takaku K, 1999, CANCER RES, V59, P6113

[145] Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes [J].

Takaku, K ;

Oshima, M ;

Miyoshi, H ;

Matsui, M ;

Seldin, MF ;

Taketo, MM .

CELL, 1998, 92 (05) :645-656

[146] Smad-dependent GADD45β expression mediates delayed activation of p38 MAP kinase by TGF-β [J].

Takekawa, M ;

Tatebayashi, K ;

Itoh, F ;

Adachi, M ;

Imai, K ;

Saito, H .

EMBO JOURNAL, 2002, 21 (23) :6473-6482

[147] Regulation of cell proliferation by Smad proteins [J].

Ten Dijke, PT ;

Goumans, MJ ;

Itoh, F ;

Itoh, S .

JOURNAL OF CELLULAR PHYSIOLOGY, 2002, 191 (01) :1-16

[148] Epithelial-mesenchymal transitions in tumour progression [J].

Thiery, JP .

NATURE REVIEWS CANCER, 2002, 2 (06) :442-454

[149] Analyses of microsatellite instability and the transforming growth factor-β receptor type II gene mutation in sporadic breast cancer and their correlation with clinicopathological features [J].

Tomita, S ;

Deguchi, S ;

Miyaguni, T ;

Muto, Y ;

Tamamoto, T ;

Toda, T .

BREAST CANCER RESEARCH AND TREATMENT, 1999, 53 (01) :33-39

[150] A HIGHLY IMMUNOGENIC TUMOR TRANSFECTED WITH A MURINE TRANSFORMING GROWTH-FACTOR TYPE-BETA-1 CDNA ESCAPES IMMUNE SURVEILLANCE [J].

TORREAMIONE, G ;

BEAUCHAMP, RD ;

KOEPPEN, H ;

PARK, BH ;

SCHREIBER, H ;

MOSES, HL ;

ROWLEY, DA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (04) :1486-1490

← 9 10 11 12 13 14 15 16 17 18 →