Poly-γ-glutamate synthetase of Bacillus subtilis

被引:50
作者
Ashiuchi, M [1 ]
Kamei, T [1 ]
Misono, H [1 ]
机构
[1] Kochi Univ, Dept Bioresources Sci, Nankoku, Kochi 7838502, Japan
关键词
poly-gamma-glutamate; synthetase; amide ligase; membranous enzyme; complex; Bacillus subtilis;
D O I
10.1016/S1381-1177(03)00076-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Poly-gamma-glutamate (PGA) is a most promising biodegradable polymer. In extracellular mucilage-producing Bacillus subtilis, the pgsBCA genes encode the membrane-associated PGA synthetase complex. It was recently speculated that PGA synthetase consists of both the intact 44 kDa and the in-phase overlapping 33 kDa-ywsC (corresponding to pgsB) gene products. This review covers current research into B. subtilis PGA synthetase and discusses the structural and functional features of the enzyme. (C) 2003 Elsevier B.V. All rights reserved.
引用
收藏
页码:101 / 106
页数:6
相关论文
共 32 条
[21]   The cell wall polymer of the extremely halophilic archaeon Natronococcus occultus [J].
Niemetz, R ;
Karcher, U ;
Kandler, O ;
Tindall, BJ ;
Konig, H .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1997, 249 (03) :905-911
[22]   Occurrence, functions and biosynthesis of polyamides in microorganisms and biotechnological production [J].
Oppermann-Sanio, FB ;
Steinbüchel, A .
NATURWISSENSCHAFTEN, 2002, 89 (01) :11-22
[23]  
Pérez-Camero G, 1999, BIOTECHNOL BIOENG, V63, P110, DOI 10.1002/(SICI)1097-0290(19990405)63:1<110::AID-BIT11>3.0.CO
[24]  
2-T
[25]   The production of poly-(γ-glutamic acid) from microorganisms and its various applications [J].
Shih, IL ;
Van, YT .
BIORESOURCE TECHNOLOGY, 2001, 79 (03) :207-225
[27]  
TROY FA, 1973, J BIOL CHEM, V248, P316
[28]   Characterization of the Bacillus subtilis ywsC gene, involved in γ-polyglutamic acid production [J].
Urushibata, Y ;
Tokuyama, S ;
Tahara, Y .
JOURNAL OF BACTERIOLOGY, 2002, 184 (02) :337-343
[29]   GRAMICIDIN-S SYNTHETASE - TEMPERATURE-DEPENDENCE AND THERMODYNAMIC PARAMETERS OF SUBSTRATE AMINO-ACID ACTIVATION REACTIONS [J].
VATER, J ;
MALLOW, N ;
GERHARDT, S ;
GADOW, A ;
KLEINKAUF, H .
BIOCHEMISTRY, 1985, 24 (08) :2022-2027
[30]  
WEBER J, 1990, J BIOL CHEM, V265, P9664