Synthesis of naturally occurring phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P3] and its diastereoisomers

被引：38

作者：

Gaffney, PRJ ^{[1
]}

Reese, CB ^{[1
]}

机构：

[1] Kings Coll London, Dept Chem, London WC2R 2LS, England

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 2001年 / 02期

关键词：

D O I：

10.1039/b007267m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The chemical synthesis of naturally occurring phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P-3] 2, in which the 1- and 2-hydroxy functions of the glycerol moiety are esterified with stearic and arachidonic acid, respectively, is described. The synthesis of three diastereoisomers 41, 42 and 43 of PtdIns(3,4,5)P-3 is also reported.

引用

页码：192 / 205

页数：14

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