Cracking the histone code: One, two, three methyls, you're out!

被引：39

作者：

Dutnall, RN ^{[1
]}

机构：

[1] Univ Calif San Diego, Div Biol Sci, Mol Biol Sect, La Jolla, CA 92093 USA

来源：

MOLECULAR CELL | 2003年 / 12卷 / 01期

关键词：

D O I：

10.1016/S1097-2765(03)00282-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this issue of Molecular Cell, Zhang et al. report the structure of a ternary complex between the SET domain histone methyltransferase DIM-5, its cofactor, and a histone H3 peptide. The insight gained from analysis of a key amino acid provides an exciting opportunity to dissect the possible functional meaning of mono-, di-, and trimethylation of histone lysine residues in vivo that will complement existing approaches in the quest to crack the histone methylation code.

引用

页码：3 / 4

页数：2

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