Emerging technologies in yeast genomics

被引:70
作者
Kumar, A [1 ]
Snyder, M [1 ]
机构
[1] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA
关键词
D O I
10.1038/35066084
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The genomic revolution is undeniable: in the past year alone, the term 'genomics' was found in nearly 500 research articles, and at least 6 journals are devoted solely to genomic biology. More than just a buzzword, molecular biology has genuinely embraced genomics (the systematic, large-scale study of genomes and their functions). With its facile genetics, the budding yeast Saccharomyces cerevisiae has emerged as an important model organism in the development of many current genomic methodologies. These techniques have greatly influenced the manner in which biology is studied in yeast and in other organisms. In this review, we summarize the most. promising technologies in yeast genomics.
引用
收藏
页码:302 / 312
页数:11
相关论文
共 71 条
  • [1] Protein microchips: Use for immunoassay and enzymatic reactions
    Arenkov, P
    Kukhtin, A
    Gemmell, A
    Voloshchuk, S
    Chupeeva, V
    Mirzabekov, A
    [J]. ANALYTICAL BIOCHEMISTRY, 2000, 278 (02) : 123 - 131
  • [2] Yeast genes and human disease
    Bassett, DE
    Boguski, MS
    Hieter, P
    [J]. NATURE, 1996, 379 (6566) : 589 - 590
  • [3] Genome cross-referencing and XREFdb: Implications for the identification and analysis of genes mutated in human disease
    Bassett, DE
    Boguski, MS
    Spencer, F
    Reeves, R
    Kim, SH
    Weaver, T
    Hieter, P
    [J]. NATURE GENETICS, 1997, 15 (04) : 339 - 344
  • [4] Clustering of meiotic double-strand breaks on yeast chromosome III
    Baudat, F
    Nicolas, A
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (10) : 5213 - 5218
  • [5] A SIMPLE AND EFFICIENT METHOD FOR DIRECT GENE DELETION IN SACCHAROMYCES-CEREVISIAE
    BAUDIN, A
    OZIERKALOGEROPOULOS, O
    DENOUEL, A
    LACROUTE, F
    CULLIN, C
    [J]. NUCLEIC ACIDS RESEARCH, 1993, 21 (14) : 3329 - 3330
  • [6] A simple in vitro Tn7-based transposition system with low target site selectivity for genome and gene analysis
    Biery, MC
    Stewart, FJ
    Stellwagen, AE
    Raleigh, EA
    Craig, NL
    [J]. NUCLEIC ACIDS RESEARCH, 2000, 28 (05) : 1067 - 1077
  • [7] Understanding gene and allele function with two-hybrid methods
    Brent, R
    Finley, RL
    [J]. ANNUAL REVIEW OF GENETICS, 1997, 31 : 663 - 704
  • [8] Knowledge-based analysis of microarray gene expression data by using support vector machines
    Brown, MPS
    Grundy, WN
    Lin, D
    Cristianini, N
    Sugnet, CW
    Furey, TS
    Ares, M
    Haussler, D
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (01) : 262 - 267
  • [9] LARGE-SCALE ANALYSIS OF GENE-EXPRESSION, PROTEIN LOCALIZATION, AND GENE DISRUPTION SACCHAROMYCES-CEREVISIAE
    BURNS, N
    GRIMWADE, B
    ROSSMACDONALD, PB
    CHOI, EY
    FINBERG, K
    ROEDER, GS
    SNYDER, M
    [J]. GENES & DEVELOPMENT, 1994, 8 (09) : 1087 - 1105
  • [10] A chemical genomics approach toward understanding the global functions of the target of rapamycin protein (TOR)
    Chan, TF
    Carvalho, J
    Riles, L
    Zheng, XFS
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (24) : 13227 - 13232