Trace element concentrations in hair of healthy Chinese centenarians

被引:48
作者
Li, Yonghua [1 ]
Yang, Linsheng [1 ]
Wang, Wuyi [1 ]
Li, Hairong [1 ]
Lv, Jinmei [1 ]
Zou, Xiaoyan [1 ]
机构
[1] Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, Beijing 100101, Peoples R China
基金
美国国家科学基金会;
关键词
Ageing; Centenarians; Hair; Human health; Trace element; SCALP HAIR; GREEK CENTENARIANS; REFERENCE VALUES; ELDERLY-PEOPLE; POPULATION; COPPER; BLOOD; SERUM; ZINC; DEFICIENCY;
D O I
10.1016/j.scitotenv.2011.01.017
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Trace element concentrations, as indicators of micronutrient status of healthy centenarians, have not been widely analyzed. This study aimed to assess trace element concentrations in the hair of healthy centenarians. The effects of gender and age on element concentrations were also investigated. Eleven trace elements (Al, Ba, Cd, Cr, Cu, Fe, Mo, Pb, Se, Sr and Zn) in the scalp hair of 107 healthy Chinese centenarians were examined. The overall reference values (RVs) in mg/kg for the hair concentrations of trace elements in centenarians were as follows: Al, 14.95; Ba, 2.68; Cd, 0.06; Cr, 0.59; Cu, 6.21); Fe, 19.37; Mo, 0.50; Pb, 4.64; Se, 0.37; Sr, 4.84; and Zn, 154.37. Data analysis found that only Cu and Zn concentrations show a normal distribution, and there is no significant difference between males and females in any element except Zn. However, the levels of Al, Cd, Cr, Fe, Mo, Pb decrease and the levels of Ba, Cu, Se, Sr, Zn increase with age in the centenarian cohort. Results also revealed that sufficient Zn and Se concentrations as well as low exposure to heavy metals pollution contribute to the longevity of centenarians. The results imply the possibility of manipulating trace element concentrations, especially Zn and Se concentrations in tissues, as a means for therapeutic modality in geriatric disease. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码:1385 / 1390
页数:6
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