Matrix metalloproteinase degradation of extracellular matrix: biological consequences

被引：604

作者：

Shapiro, SD

机构：

[1] Washington Univ, Sch Med, Dept Pediat, Barnes Jewish Hosp, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Barnes Jewish Hosp, Dept Med & Cell Biol, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Dept Physiol, Barnes Jewish Hosp, St Louis, MO 63110 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1998年 / 10卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0955-0674(98)80035-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Targeted mutagenesis has allowed investigators to perform controlled experiments in mammals and determine the contribution of individual proteins to physiologic and pathologic processes. Recent lessons learned from matrix metalloproteinase gene targeted mice and other in vivo observations have given new life to old concepts regarding the role of proteolytic fragments of extracellular matrix proteins in regulating a variety of critical processes in cell biology.

引用

页码：602 / 608

页数：7

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[11] Macrophage-derived metalloelastase is responsible for the generation of angiostatin in Lewis lung carcinoma [J].