Aging: A Temporal Dimension for Neutrophils

被引：171

作者：

Adrover, Jose M. ^{[1
]}

Nicolas-Avila, Jose A. ^{[1
]}

Hidalgo, Andres ^{[1
]}

机构：

[1] Fdn Ctr Nacl Invest Cardiovasc CNIC, Area Cell & Dev Biol, Madrid 28029, Spain

来源：

TRENDS IN IMMUNOLOGY | 2016年 / 37卷 / 05期

关键词：

HEMATOPOIETIC STEM-CELLS; LIVER X RECEPTORS; BONE-MARROW; POLYMORPHONUCLEAR LEUKOCYTES; CIRCADIAN CLOCK; IMMUNE-SYSTEM; LYMPH-NODES; CLEARANCE; INFLAMMATION; MICE;

D O I：

10.1016/j.it.2016.03.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Neutrophils are first-responders, providing early protection against invading pathogens. Recent findings have revealed a temporal dimension to neutrophil function, associated with the clearance cycles for aging neutrophils, and also with a program that endows circulating neutrophils with distinct phenotypic and functional properties at different times of the day, before they are cleared from blood. We review here the process of neutrophil aging and its impact on homeostasis and inflammation. We outline the features of aged neutrophils, examine proposed mechanisms that drive aging, and discuss how these processes may contribute to tissue homeostasis and pathology. In this context we propose that neutrophil aging may optimize host defense by allowing neutrophils to anticipate infections while avoiding permanent activation and subsequent damage.

引用

页码：334 / 345

页数：12

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