Structural genomics: from genes to structures with valuable materials and many questions in between

被引：31

作者：

Fox, Brian G. ^{[1
]}

Goulding, Celia ^{[2
]}

Malkowski, Michael G. ^{[3
]}

Stewart, Lance ^{[4
]}

Deacon, Ashley ^{[5
]}

机构：

[1] Univ Wisconsin, Ctr Eukaryot Struct Genom, Madison, WI 53706 USA

[2] Univ Calif Los Angeles, Integrated Ctr Struct & Funct Innovat, Inst Mol Biol, Los Angeles, CA 90095 USA

[3] Hauptmann Woodward Med Res Inst, Ctr High Throughput Struct Biol, Buffalo, NY 14203 USA

[4] deCODE Biostruct, Accelerated Technol Ctr Gene 3D Struct, Bainbridge Isl, WA 98110 USA

[5] Stanford Synchrotron Radiat Lab, Joint Ctr Struct Genom, Menlo Pk, CA 94025 USA

来源：

NATURE METHODS | 2008年 / 5卷 / 02期

关键词：

D O I：

10.1038/nmeth0208-129

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The Protein Structure Initiative (PSI), funded by the US National Institutes of Health (NIH), provides a framework for the development and systematic evaluation of methods to solve protein structures. Although the PSI and other structural genomics efforts around the world have led to the solution of many new protein structures as well as the development of new methods, methodological bottlenecks still exist and are being addressed in this ' production phase' of PSI.

引用

页码：129 / 132

页数：4

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