DNA-DNA interstrand cross-linking by FR66979 and FR900482: Requirement of metal ions during reductive activation

被引：27

作者：

Paz, MM ^{[1
]}

Hopkins, PB ^{[1
]}

机构：

[1] UNIV WASHINGTON,DEPT CHEM,SEATTLE,WA 98195

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(96)02347-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The antitumor antibiotics FR66979 and FR900482 are believed to undergo bioreductive activation in vivo, enabling them to alkylate DNA. Reduction has previously been accomplished in vitro using sodium dithionite or dithiothreitol. We find that metal ions are a previously unrecognized, critical component of these reactions,which are suppressed by addition of EDTA and greatly stimulated by addition of catalytic quantities of iron(ll) salts. This finding should greatly facilitate the elucidation of the details of the reaction cascades which follow reductive activation. Copyright (C) 1996 Elsevier Science Ltd

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页码：343 / 346

页数：4

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