The nucleolus: a site of ribonucleoprotein maturation

被引：96

作者：

Gerbi, SA ^{[1
]}

Borovjagin, AV ^{[1
]}

Lange, TS ^{[1
]}

机构：

[1] Brown Univ, Dept Mol Biol Cell Biol & Biochem, Div Biol & Med, JW Wilson Lab, Providence, RI 02912 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2003年 / 15卷 / 03期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

D O I：

10.1016/S0955-0674(03)00049-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The nucleolus is the site of ribosomal RNA synthesis, processing and ribosome maturation. Various small ribonucleoproteins also undergo maturation in the nucleolus, involving RNA modification and RNA-protein assembly. Such steps and other activities of small ribonucleoproteins also take place in Cajal (coiled) bodies. Events of ribosome biogenesis are found solely-in the nucleolus, which is the final destination of small nucleolar RNAs after their traffic through Cajal bodies. However, nucleoli are just a stopping point in the intricate cellular traffic for small nuclear RNAs and other ribonucleoproteins.

引用

收藏

页码：318 / 325

页数：8

相关论文

共 57 条

[1] p110, a novel human U6 snRNP protein and U4/U6 snRNP recycling factor [J].

Bell, M ;

Schreiner, S ;

Damianov, A ;

Reddy, R ;

Bindereif, A .

EMBO JOURNAL, 2002, 21 (11) :2724-2735

[2] BASE-PAIRING BETWEEN U3 AND THE PRE-RIBOSOMAL-RNA IS REQUIRED FOR 18S RIBOSOMAL-RNA SYNTHESIS [J].

BELTRAME, M ;

TOLLERVEY, D .

EMBO JOURNAL, 1995, 14 (17) :4350-4356

[3] Nucleolar localization of early tRNA processing [J].

Bertrand, E ;

Houser-Scott, F ;

Kendall, A ;

Singer, RH ;

Engelke, DR .

GENES & DEVELOPMENT, 1998, 12 (16) :2463-2468

[4] The spacing between functional cis-elements of U3 snoRNA is critical for rRNA processing [J].

Borovjagin, AV ;

Gerbi, SA .

JOURNAL OF MOLECULAR BIOLOGY, 2000, 300 (01) :57-74

[5] U3 small nucleolar RNA is essential for cleavage at sites 1, 2 and 3 in pre-rRNA and determines which rRNA processing pathway is taken in Xenopus oocytes [J].

Borovjagin, AV ;

Gerbi, SA .

JOURNAL OF MOLECULAR BIOLOGY, 1999, 286 (05) :1347-1363

[6] Xenopus U3 snoRNA GAC-box A′ and box A sequences play distinct functional roles in rRNA processing [J].

Borovjagin, AV ;

Gerbi, SA .

MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (18) :6210-6221

[7] Cajal body-specific small nuclear RNAs:: a novel class of 2′-O-methylation and pseudouridylation guide RNAs [J].

Darzacq, X ;

Jády, BE ;

Verheggen, C ;

Kiss, AM ;

Bertrand, E ;

Kiss, T .

EMBO JOURNAL, 2002, 21 (11) :2746-2756

[8] A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis [J].

Dragon, F ;

Gallagher, JEG ;

Compagnone-Post, PA ;

Mitchell, BM ;

Porwancher, KA ;

Wehner, KA ;

Wormsley, S ;

Settlage, RE ;

Shabanowitz, J ;

Osheim, Y ;

Beyer, AL ;

Hunt, DF ;

Baserga, SJ .

NATURE, 2002, 417 (6892) :967-970

[9] The nucleolar localization domain of the catalytic subunit of human telomerase [J].

Etheridge, KT ;

Banik, SSR ;

Armbruster, BN ;

Zhu, YS ;

Terns, RM ;

Terns, MP ;

Counter, CM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (27) :24764-24770

[10] Biogenesis of small nucleolar ribonucleoproteins [J].

Filipowicz, W ;

Pogacic, V .

CURRENT OPINION IN CELL BIOLOGY, 2002, 14 (03) :319-327

← 1 2 3 4 5 6 →