New links between vesicle coats and Rab-mediated vesicle targeting

被引：56

作者：

Angers, Cortney G. ^{[1
]}

Merz, Alexey J. ^{[1
]}

机构：

[1] Univ Washington, Sch Med, Dept Biochem, Seattle, WA 98195 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2011年 / 22卷 / 01期

关键词：

Rab GTPase; Tether; Vesicle trafficking; Adaptor; Vesicle coat; Uncoating; ADP-RIBOSYLATION FACTOR; GTP-BINDING PROTEIN; ENDOPLASMIC RETICULUM RETRIEVAL; PERIPHERAL MEMBRANE-PROTEIN; OLIGOMERIC GOLGI-COMPLEX; TRANS-SNARE COMPLEXES; TO-TGN TRANSPORT; VACUOLE FUSION; YEAST VACUOLE; TETHERING COMPLEX;

D O I：

10.1016/j.semcdb.2010.07.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Vesicle trafficking is a highly regulated process that transports proteins and other cargoes through eukaryotic cells while maintaining cellular organization and compartmental identity. In order for cargo to reach the correct destination, each step of trafficking must impart specificity. During vesicle formation, this is achieved by coat proteins, which selectively incorporate cargo into the nascent vesicle. Classically, vesicle coats are thought to dissociate shortly after budding. However, recent studies suggest that coat proteins can remain on the vesicle en route to their destination, imparting targeting specificity by physically and functionally interacting with Rab-regulated tethering systems. This review focuses on how interactions among Rab GTPases, tethering factors, SNARE proteins, and vesicle coats contribute to vesicle targeting, fusion, and coat dynamics. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：18 / 26

页数：9

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