DNMT3A mutations in acute myeloid leukemia

被引：45

作者：

Shah, Mrinal Y. ^{[1
]}

Licht, Jonathan D. ^{[1
]}

机构：

[1] Northwestern Univ, Div Hematol & Oncol, Chicago, IL 60611 USA

来源：

NATURE GENETICS | 2011年 / 43卷 / 04期

关键词：

DNA METHYLTRANSFERASE; HEMATOPOIETIC STEM; DIFFERENTIATION; CELLS; HYPERMETHYLATION; 5-METHYLCYTOSINE; METHYLATION; TET2;

D O I：

10.1038/ng0411-289

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

New studies reveal that 20% of individuals with acute myeloid leukemia harbor somatic mutations in DNMT3A (encoding DNA methyltransferase 3A). Although these leukemias have some gene expression and DNA methylation changes, a direct link between mutant DNMT3A, epigenetic changes and pathogenesis remains to be established.

引用

页码：289 / 290

页数：3

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