Enhancing catalytic promiscuity for biocatalysis

被引：190

作者：

Kazlauskas, RJ ^{[1
]}

机构：

[1] Univ Minnesota, Dept Biochem, Mol Biol & Biophys & Biotechnol Inst, St Paul, MN 55108 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2005年 / 9卷 / 02期

关键词：

D O I：

10.1016/j.cbpa.2005.02.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Catalytic promiscuity - the ability of a single active site to catalyse more than one chemical transformation - has a natural role in evolution and occasionally in biosynthesis of secondary metabolites. Catalytic promiscuity is more widespread than often recognized. Recent success in adding and enhancing such catalytic activities by protein engineering suggests new potential applications in enzyme-catalyzed organic synthesis.

引用

页码：195 / 201

页数：7

共 35 条

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