Shrink-Film Configurable Multiscale Wrinkles for Functional Alignment of Human Embryonic Stem Cells and their Cardiac Derivatives

被引：101

作者：

Chen, Aaron ^{[2
]}

Lieu, Deborah K. ^{[3
]}

Freschauf, Lauren ^{[4
]}

Lew, Valerie ^{[4
]}

Sharma, Himanshu ^{[2
]}

Wang, Jiaxian ^{[1
,5
]}

Diep Nguyen ^{[4
]}

Karakikes, Ioannis ^{[5
]}

Hajjar, Roger J. ^{[5
]}

Gopinathan, Ajay ^{[6
]}

Botvinick, Elliot ^{[4
]}

Fowlkes, Charless C. ^{[4
,7
]}

Li, Ronald A. ^{[1
,5
,8
]}

Khine, Michelle ^{[2
,4
]}

机构：

[1] Univ Hong Kong, LKS Fac Med, Stem Cell & Regenerat Med Consortium, Pokfulam, Hong Kong, Peoples R China

[2] Univ Calif Irvine, Dept Chem Engn & Mat Sci, Irvine, CA 92697 USA

[3] Univ Calif Davis, Dept Internal Med, Div Cardiovasc Med, Davis, CA 95616 USA

[4] Univ Calif Irvine, Dept Biomed Engn, Irvine, CA 92697 USA

[5] Mt Sinai Sch Med, Cardiovasc Res Ctr, New York, NY 10029 USA

[6] Univ Calif Merced, Sch Nat Sci, Merced, CA 95344 USA

[7] Univ Calif Irvine, Dept Comp Sci, Irvine, CA 92697 USA

[8] Univ Hong Kong, LKS Fac Med, Dept Physiol & Med, Heart Brain Hormone & Hlth Aging Res Ctr, Hong Kong, Hong Kong, Peoples R China

来源：

ADVANCED MATERIALS | 2011年 / 23卷 / 48期

关键词：

biomimetics; human embryonic stem cell derived cardiomyocytes; contact guidance; action potential propagation; NANOSCALE; TOPOGRAPHY; DIFFERENTIATION; CARDIOMYOCYTES; FIBROBLASTS; NUCLEUS;

D O I：

10.1002/adma.201103463

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A biomimetic substrate for cell-culture is fabricated by plasma treatment of a prestressed thermoplastic shrink film to create tunable multiscaled alignment "wrinkles". Using this substrate, the functional alignment of human embryonic stem cell derived cardiomyocytes is demonstrated.

引用

页码：5785 / +

页数：8

共 32 条

[1] Interactive effects of surface topography and pulsatile electrical field stimulation on orientation and elongation of fibroblasts and cardiomyocytes [J].

Au, Hoi Ting H. ;

Cheng, Irene ;

Chowdhury, Mohammad F. ;

Radisic, Milica .

BIOMATERIALS, 2007, 28 (29) :4277-4293

[2] Cell culture chips for simultaneous application of topographical and electrical cues enhance phenotype of cardiomyocytes [J].

Au, Hoi Ting Heidi ;

Cui, Bo ;

Chu, Zane E. ;

Veres, Teodor ;

Radisic, Milica .

LAB ON A CHIP, 2009, 9 (04) :564-575

[3] Engineering Substrate Topography at the Micro- and Nanoscale to Control Cell Function [J].

Bettinger, Christopher J. ;

Langer, Robert ;

Borenstein, Jeffrey T. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (30) :5406-5415

[4] Spontaneous formation of ordered structures in thin films of metals supported on an elastomeric polymer [J].

Bowden, N ;

Brittain, S ;

Evans, AG ;

Hutchinson, JW ;

Whitesides, GM .

NATURE, 1998, 393 (6681) :146-149

[5] Geometric control of cell life and death [J].

Chen, CS ;

Mrksich, M ;

Huang, S ;

Whitesides, GM ;

Ingber, DE .

SCIENCE, 1997, 276 (5317) :1425-1428

[6] Nanomechanotransduction and interphase nuclear organization influence on genomic control [J].

Dalby, Matthew J. ;

Gadegaard, Nikolaj ;

Herzyk, Pawel ;

Sutherland, Duncan ;

Agheli, Hossein ;

Wilkinson, Chris D. W. ;

Curtis, Adam S. G. .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2007, 102 (05) :1234-1244

[7] The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder [J].

Dalby, Matthew J. ;

Gadegaard, Nikolaj ;

Tare, Rahul ;

Andar, Abhay ;

Riehle, Mathis O. ;

Herzyk, Pawel ;

Wilkinson, Chris D. W. ;

Oreffo, Richard O. C. .

NATURE MATERIALS, 2007, 6 (12) :997-1003

[8] Nucleus alignment and cell signaling in fibroblasts: response to a micro-grooved topography [J].

Dalby, MJ ;

Riehle, MO ;

Yarwood, SJ ;

Wilkinson, CDW ;

Curtis, ASG .

EXPERIMENTAL CELL RESEARCH, 2003, 284 (02) :274-282

[9] Development and Testing of Hierarchically Wrinkled Coatings for Marine Antifouling [J].

Efimenko, Kirill ;

Finlay, John ;

Callow, Maureen E. ;

Callow, James A. ;

Genzer, Jan .

ACS APPLIED MATERIALS & INTERFACES, 2009, 1 (05) :1031-1040

[10] Accordion-like honeycombs for tissue engineering of cardiac anisotropy [J].

Engelmayr, George C., Jr. ;

Cheng, Mingyu ;

Bettinger, Christopher J. ;

Borenstein, Jeffrey T. ;

Langer, Robert ;

Freed, Lisa E. .

NATURE MATERIALS, 2008, 7 (12) :1003-1010

← 1 2 3 4 →