Shrink-Film Configurable Multiscale Wrinkles for Functional Alignment of Human Embryonic Stem Cells and their Cardiac Derivatives

被引：101

作者：

Chen, Aaron ^{[2
]}

Lieu, Deborah K. ^{[3
]}

Freschauf, Lauren ^{[4
]}

Lew, Valerie ^{[4
]}

Sharma, Himanshu ^{[2
]}

Wang, Jiaxian ^{[1
,5
]}

Diep Nguyen ^{[4
]}

Karakikes, Ioannis ^{[5
]}

Hajjar, Roger J. ^{[5
]}

Gopinathan, Ajay ^{[6
]}

Botvinick, Elliot ^{[4
]}

Fowlkes, Charless C. ^{[4
,7
]}

Li, Ronald A. ^{[1
,5
,8
]}

Khine, Michelle ^{[2
,4
]}

机构：

[1] Univ Hong Kong, LKS Fac Med, Stem Cell & Regenerat Med Consortium, Pokfulam, Hong Kong, Peoples R China

[2] Univ Calif Irvine, Dept Chem Engn & Mat Sci, Irvine, CA 92697 USA

[3] Univ Calif Davis, Dept Internal Med, Div Cardiovasc Med, Davis, CA 95616 USA

[4] Univ Calif Irvine, Dept Biomed Engn, Irvine, CA 92697 USA

[5] Mt Sinai Sch Med, Cardiovasc Res Ctr, New York, NY 10029 USA

[6] Univ Calif Merced, Sch Nat Sci, Merced, CA 95344 USA

[7] Univ Calif Irvine, Dept Comp Sci, Irvine, CA 92697 USA

[8] Univ Hong Kong, LKS Fac Med, Dept Physiol & Med, Heart Brain Hormone & Hlth Aging Res Ctr, Hong Kong, Hong Kong, Peoples R China

来源：

ADVANCED MATERIALS | 2011年 / 23卷 / 48期

关键词：

biomimetics; human embryonic stem cell derived cardiomyocytes; contact guidance; action potential propagation; NANOSCALE; TOPOGRAPHY; DIFFERENTIATION; CARDIOMYOCYTES; FIBROBLASTS; NUCLEUS;

D O I：

10.1002/adma.201103463

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A biomimetic substrate for cell-culture is fabricated by plasma treatment of a prestressed thermoplastic shrink film to create tunable multiscaled alignment "wrinkles". Using this substrate, the functional alignment of human embryonic stem cell derived cardiomyocytes is demonstrated.

引用

页码：5785 / +

页数：8

共 32 条

[21] Mechano-topographic modulation of stem cell nuclear shape on nanofibrous scaffolds [J].

Nathan, Ashwin S. ;

Baker, Brendon M. ;

Nerurkar, Nandan L. ;

Mauck, Robert L. .

ACTA BIOMATERIALIA, 2011, 7 (01) :57-66

[22] Cooperation of Biological and Mechanical Signals in Cardiac Progenitor Cell Differentiation [J].

Pagliari, Stefania ;

Vilela-Silva, Ana Cristina ;

Forte, Giancarlo ;

Pagliari, Francesca ;

Mandoli, Corrado ;

Vozzi, Giovanni ;

Pietronave, Stefano ;

Prat, Maria ;

Licoccia, Silvia ;

Ahluwalia, Arti ;

Traversa, Enrico ;

Minieri, Marilena ;

Di Nardo, Paolo .

ADVANCED MATERIALS, 2011, 23 (04) :514-+

[23] Physical plasticity of the nucleus in stem cell differentiation [J].

Pajerowski, J. David ;

Dahl, Kris Noel ;

Zhong, Franklin L. ;

Sammak, Paul J. ;

Discher, Dennis E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (40) :15619-15624

[24] Self-assembly of collagen fibers. Influence of fibrillar alignment and decorin on mechanical properties [J].

Pins, GD ;

Christiansen, DL ;

Patel, R ;

Silver, FH .

BIOPHYSICAL JOURNAL, 1997, 73 (04) :2164-2172

[25] Multiscale three-dimensional scaffolds for soft tissue engineering via multimodal electrospinning [J].

Soliman, Sherif ;

Pagliari, Stefania ;

Rinaldi, Antonio ;

Forte, Giancarlo ;

Fiaccavento, Roberta ;

Pagliari, Francesca ;

Franzese, Ornella ;

Minieri, Marilena ;

Di Nardo, Paolo ;

Licoccia, Silvia ;

Traversa, Enrico .

ACTA BIOMATERIALIA, 2010, 6 (04) :1227-1237

[26] Physiological function and transplantation of scaffold-free and vascularized human cardiac muscle tissue [J].

Stevens, K. R. ;

Kreutziger, K. L. ;

Dupras, S. K. ;

Korte, F. S. ;

Regnier, M. ;

Muskheli, V. ;

Nourse, M. B. ;

Bendixen, K. ;

Reinecke, H. ;

Murry, C. E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (39) :16568-16573

[27] Analyzing shear stress-induced alignment of actin filaments in endothelial cells with a microfluidic assay [J].

van der Meer, A. D. ;

Poot, A. A. ;

Feijen, J. ;

Vermes, I. .

BIOMICROFLUIDICS, 2010, 4 (01)

[28] CELL-SHAPE CONTROLS TERMINAL DIFFERENTIATION OF HUMAN EPIDERMAL-KERATINOCYTES [J].

WATT, FM ;

JORDAN, PW ;

ONEILL, CH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (15) :5576-5580

[29] Feeder-free growth of undifferentiated human embryonic stem cells [J].

Xu, CH ;

Inokuma, MS ;

Denham, J ;

Golds, K ;

Kundu, P ;

Gold, JD ;

Carpenter, MK .

NATURE BIOTECHNOLOGY, 2001, 19 (10) :971-974

[30] Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes -: Insights into the development of cell-based pacemakers [J].

Xue, T ;

Cho, HC ;

Akar, FG ;

Tsang, SY ;

Jones, SP ;

Marbán, E ;

Tomaselli, GF ;

Li, RA .

CIRCULATION, 2005, 111 (01) :11-20

← 1 2 3 4 →