Shrink-Film Configurable Multiscale Wrinkles for Functional Alignment of Human Embryonic Stem Cells and their Cardiac Derivatives

被引：101

作者：

Chen, Aaron ^{[2
]}

Lieu, Deborah K. ^{[3
]}

Freschauf, Lauren ^{[4
]}

Lew, Valerie ^{[4
]}

Sharma, Himanshu ^{[2
]}

Wang, Jiaxian ^{[1
,5
]}

Diep Nguyen ^{[4
]}

Karakikes, Ioannis ^{[5
]}

Hajjar, Roger J. ^{[5
]}

Gopinathan, Ajay ^{[6
]}

Botvinick, Elliot ^{[4
]}

Fowlkes, Charless C. ^{[4
,7
]}

Li, Ronald A. ^{[1
,5
,8
]}

Khine, Michelle ^{[2
,4
]}

机构：

[1] Univ Hong Kong, LKS Fac Med, Stem Cell & Regenerat Med Consortium, Pokfulam, Hong Kong, Peoples R China

[2] Univ Calif Irvine, Dept Chem Engn & Mat Sci, Irvine, CA 92697 USA

[3] Univ Calif Davis, Dept Internal Med, Div Cardiovasc Med, Davis, CA 95616 USA

[4] Univ Calif Irvine, Dept Biomed Engn, Irvine, CA 92697 USA

[5] Mt Sinai Sch Med, Cardiovasc Res Ctr, New York, NY 10029 USA

[6] Univ Calif Merced, Sch Nat Sci, Merced, CA 95344 USA

[7] Univ Calif Irvine, Dept Comp Sci, Irvine, CA 92697 USA

[8] Univ Hong Kong, LKS Fac Med, Dept Physiol & Med, Heart Brain Hormone & Hlth Aging Res Ctr, Hong Kong, Hong Kong, Peoples R China

来源：

ADVANCED MATERIALS | 2011年 / 23卷 / 48期

关键词：

biomimetics; human embryonic stem cell derived cardiomyocytes; contact guidance; action potential propagation; NANOSCALE; TOPOGRAPHY; DIFFERENTIATION; CARDIOMYOCYTES; FIBROBLASTS; NUCLEUS;

D O I：

10.1002/adma.201103463

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A biomimetic substrate for cell-culture is fabricated by plasma treatment of a prestressed thermoplastic shrink film to create tunable multiscaled alignment "wrinkles". Using this substrate, the functional alignment of human embryonic stem cell derived cardiomyocytes is demonstrated.

引用

页码：5785 / +

页数：8

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