Synthesis of 64CuII-Bis(dithiocarbamatebisphosphonate) and Its Conjugation with Superparamagnetic Iron Oxide Nanoparticles: In Vivo Evaluation as Dual-Modality PET-MRI Agent

被引：150

作者：

de Rosales, Rafael Torres Martin ^{[1
]}

Tavare, Richard ^{[1
]}

Paul, Rowena L. ^{[1
]}

Jauregui-Osoro, Maite ^{[1
]}

Protti, Andrea ^{[1
]}

Glaria, Arnaud ^{[1
]}

Varma, Gopal ^{[1
]}

Szanda, Istvan ^{[1
]}

Blower, Philip J. ^{[1
]}

机构：

[1] Kings Coll London, St Thomas Hosp, Div Imaging Sci & Biomed Engn, London SE1 7EH, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 24期

基金：

英国工程与自然科学研究理事会; 英国惠康基金;

关键词：

chelates; copper; imaging agents; nanoparticles; rare earths; CU-64-LABELED MAGNETIC NANOPARTICLES; POSITRON-EMISSION-TOMOGRAPHY; CONTRAST AGENTS; COMPLEXES; PHOSPHONATES; DIAGNOSIS; PLATFORM; SYSTEM; PROBES;

D O I：

10.1002/anie.201007894

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A novel bifunctional chelator combines a dithiocarbamate group for binding the positron-emitter 64Cu (red spheres) for PET imaging and a bisphosphonate group (green ellipsoids) for strong binding to several inorganic materials, such as MRI contrast agents based on superparamagnetic iron oxide nanoparticles and rare-earth metal oxides. The dual PET-MR imaging capabilities of this approach are demonstrated invivo by imaging lymph nodes using both imaging modalities. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：5509 / 5513

页数：5

共 50 条

[1]

Cobalt phosphonates: An unusual polymeric cobalt phosphonate containing a clathrated phosphonate anion and a layered bisphosphonate [J].

Bakhmutova, EV ;

Ouyang, X ;

Medvedev, DG ;

Clearfield, A .

INORGANIC CHEMISTRY, 2003, 42 (22) :7046-7051

[2]

Imaging of the lymphatic system: new horizons [J].

Barrett, Tristan ;

Choyke, Peter L. ;

Kobayashi, Hisataka .

CONTRAST MEDIA & MOLECULAR IMAGING, 2006, 1 (06) :230-245

[3]

Superparamagnetic nanovector with anti-cancer properties: γFe2O3@Zoledronate [J].

Benyettou, Farah ;

Lalatonne, Yoann ;

Sainte-Catherine, Odile ;

Monteil, Maelle ;

Motte, Laurence .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2009, 379 (02) :324-327

[4]

Bhushan K. R., 2007, ANGEW CHEM, V119, P8115

[5]

Synthesis of conjugatable bisphosphonates for molecular imaging of large animals [J].

Bhushan, Kumar R. ;

Tanaka, Eiichi ;

Frangioni, John V. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (42) :7969-7971

[6]

Detection of Breast Cancer Microcalcifications Using a Dual-modality SPECT/NIR Fluorescent Probe [J].

Bhushan, Kumar R. ;

Misra, Preeti ;

Liu, Fangbing ;

Mathur, Sanjeev ;

Lenkinski, Robert E. ;

Frangioni, John V. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (52) :17648-+

[7]

Iron oxide MR contrast agents for molecular and cellular imaging [J].

Bulte, JWM ;

Kraitchman, DL .

NMR IN BIOMEDICINE, 2004, 17 (07) :484-499

[8]

Simultaneous in vivo positron emission tomography and magnetic resonance imaging [J].

Catana, Ciprian ;

Procissi, Daniel ;

Wu, Yibao ;

Judenhofer, Martin S. ;

Qi, Jinyi ;

Pichler, Bernd J. ;

Jacobs, Russell E. ;

Cherry, Simon R. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (10) :3705-3710

[9]

Synergistically Integrated Nanoparticles as Multimodal Probes for Nanobiotechnology [J].

Cheon, Jinwoo ;

Lee, Jae-Hyun .

ACCOUNTS OF CHEMICAL RESEARCH, 2008, 41 (12) :1630-1640

[10]

Choi J., 2008, ANGEW CHEM, V120, P6355

← 1 2 3 4 5 →