The transmembrane adapter LAT plays a central role in immune receptor signalling

被引：23

作者：

Wonerow, P ^{[1
]}

Watson, SP ^{[1
]}

机构：

[1] Univ Oxford, Dept Pharmacol, Oxford OX1 3QT, England

来源：

ONCOGENE | 2001年 / 20卷 / 44期

基金：

英国惠康基金;

关键词：

LAT; T cell receptor signalling; glycolipid-enriched membrane domains (GEMs); adapters; platelets; signal transduction;

D O I：

10.1038/sj.onc.1204770

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The transmembrane adapter LAT (linker for activation of T cells) plays a central role in signalling by ITAM bearing receptors expressed on T cells, natural killer cells, mast cells and platelets. Receptor engagement leads to the phosphorylation of tyrosine residues present in the intracellular domain of LAT and formation of a multiprotein complex with other adapter molecules and enzymes including Grb2, Gads/SLP-76 and PLC gamma isoforms. These signalling events predominantly take place in glycolipid-enriched membrane domains. The constitutive presence of LAT in GEMs enables its function as the main scaffolding protein for the organization of GEM-localized signalling. The study of LAT-deficient mice and LAT-deficient cell lines further emphasizes the importance of LAT for these signalling cascades but also defines the existence of LAT-independent events downstream of the Syk-family kinase-ITAM complex.

引用

页码：6273 / 6283

页数：11

共 99 条

[91] A Nck-Pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNK [J].