Major gender difference in association of FTO gene variant among severely obese children with obesity and obesity related phenotypes

被引：109

作者：

Jacobsson, Josefin A. ^{[1
]}

Danielsson, Pernilla ^{[2
]}

Svensson, Victoria ^{[2
]}

Klovins, Janis ^{[1
,3
]}

Gyllensten, Ulf ^{[4
]}

Marcus, Claude ^{[2
]}

Schioth, Helgi B. ^{[1
]}

Fredriksson, Robert ^{[1
]}

机构：

[1] Uppsala Univ, Dept Neurosci Funct Pharmacol, Uppsala, Sweden

[2] Natl Childhood Obes Ctr, Div Pediat, Karolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, Sweden

[3] Univ Latvia, Biomed Res & Study Ctr, LV-1067 Riga, Latvia

[4] Uppsala Univ, Dept Gen & Pathol, Uppsala, Sweden

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2008年 / 368卷 / 03期

关键词：

FTO; obesity; SNP; diabetes; children; body mass index; insulin; glucose;

D O I：

10.1016/j.bbrc.2008.01.087

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent studies have shown that SNPs in the FTO gene predispose to childhood and adult obesity. In this study, we examined the association between variants in FTO and KIAA1005, a gene that maps closely to FTO, and obesity, as well as obesity related traits among 450 well characterised severely obese children and 512 normal weight controls. FTO showed significant association with several obesity related traits while SNPs in KIAA1005 did not. When stratified by gender, the FTO variant rs9939609 showed association with obesity and BMI among girls (P = 0.006 and 0.004, respectively) but not among boys. Gender differences were also found in the associations of the FTO rs9939609 with obesity related traits such as insulin sensitivity and plasma glucose. This study suggests that FTO may have an important role for gender specific development of severe obesity and insulin resistance in children. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：476 / 482

页数：7

共 25 条

[11] A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity [J].

Frayling, Timothy M. ;

Timpson, Nicholas J. ;

Weedon, Michael N. ;

Zeggini, Eleftheria ;

Freathy, Rachel M. ;

Lindgren, Cecilia M. ;

Perry, John R. B. ;

Elliott, Katherine S. ;

Lango, Hana ;

Rayner, Nigel W. ;

Shields, Beverley ;

Harries, Lorna W. ;

Barrett, Jeffrey C. ;

Ellard, Sian ;

Groves, Christopher J. ;

Knight, Bridget ;

Patch, Ann-Marie ;

Ness, Andrew R. ;

Ebrahim, Shah ;

Lawlor, Debbie A. ;

Ring, Susan M. ;

Ben-Shlomo, Yoav ;

Jarvelin, Marjo-Riitta ;

Sovio, Ulla ;

Bennett, Amanda J. ;

Melzer, David ;

Ferrucci, Luigi ;

Loos, Ruth J. F. ;

Barroso, Ines ;

Wareham, Nicholas J. ;

Karpe, Fredrik ;

Owen, Katharine R. ;

Cardon, Lon R. ;

Walker, Mark ;

Hitman, Graham A. ;

Palmer, Colin N. A. ;

Doney, Alex S. F. ;

Morris, Andrew D. ;

Smith, George Davey ;

Hattersley, Andrew T. ;

McCarthy, Mark I. .

SCIENCE, 2007, 316 (5826) :889-894

[12] The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase [J].

Gerken, Thomas ;

Girard, Christophe A. ;

Tung, Yi-Chun Loraine ;

Webby, Celia J. ;

Saudek, Vladimir ;

Hewitson, Kirsty S. ;

Yeo, Giles S. H. ;

McDonough, Michael A. ;

Cunliffe, Sharon ;

McNeill, Luke A. ;

Galvanovskis, Juris ;

Rorsman, Patrik ;

Robins, Peter ;

Prieur, Xavier ;

Coll, Anthony P. ;

Ma, Marcella ;

Jovanovic, Zorica ;

Farooqi, I. Sadaf ;

Sedgwick, Barbara ;

Barroso, Ines ;

Lindahl, Tomas ;

Ponting, Chris P. ;

Ashcroft, Frances M. ;

O'Rahilly, Stephen ;

Schofield, Christopher J. .

SCIENCE, 2007, 318 (5855) :1469-1472

[13] Effects of growth hormone treatment in obese prepubertal boys [J].

Kamel, A ;

Norgren, S ;

Elimam, A ;

Danielsson, P ;

Marcus, C .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (04) :1412-1419

[14] Gender-specific molecular heterosis and association studies: Dopamine D2 receptor gene and smoking [J].

Lee, HS .

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2003, 118B (01) :55-59

[15] Prevalence trends of obesity and overweight among 10-year-old children in western Sweden and relationship with parental body mass index [J].

Mårild, S ;

Bondestam, M ;

Bergström, R ;

Ehnberg, S ;

Hollsing, A ;

Albertsson-Wikland, K .

ACTA PAEDIATRICA, 2004, 93 (12) :1588-1595

[16] Prevalence of obesity in Sweden [J].

Neovius, M ;

Janson, A ;

Rössner, S .

OBESITY REVIEWS, 2006, 7 (01) :1-3

[17]

PEETERS A, 2007, MOL GENET METAB

[18] Mouse Chromosome 2 [J].

Peters, J ;

Church, D ;

Zuberi, AR ;

Selley, R .

MAMMALIAN GENOME, 1999, 10 (10) :941-941

[19] Increasing prevalence of overweight in young schoolchildren in Umea, Sweden, from 1986 to 2001 [J].

Petersen, S ;

Brulin, C ;

Bergström, E .

ACTA PAEDIATRICA, 2003, 92 (07) :848-853

[20] ADIPOSITY INDEXES IN CHILDREN [J].

ROLLANDCACHERA, MF ;

SEMPE, M ;

GUILLOUDBATAILLE, M ;

PATOIS, E ;

PEQUIGNOTGUGGENBUHL, F ;

FAUTRAD, V .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 1982, 36 (01) :178-184

← 1 2 3 →