Regulation of thymocyte development from immature progenitors

被引：139

作者：

ZunigaPflucker, JC ^{[1
]}

Lenardo, MJ ^{[1
]}

机构：

[1] NIAID,IMMUNOL LAB,NIH,BETHESDA,MD 20892

来源：

CURRENT OPINION IN IMMUNOLOGY | 1996年 / 8卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0952-7915(96)80060-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T lymphocytes differentiate from hematopoietic stem cells that settle in the microenvironment of the thymus. The earliest stages of mouse alpha/beta T-cell differentiation occurring before surface expression of the TCR include three important events: proliferation, commitment to the T lineage, and rearrangement and expression of the TCR loci. Recent evidence suggests that the survival as well as differentiation of early thymocytes depends critically on molecular signals such as those generated by the recently described pre-TCR complex.

引用

页码：215 / 224

页数：10

共 96 条

[91] CD4 EXPRESSED ON EARLIEST T-LINEAGE PRECURSOR CELLS IN THE ADULT MURINE THYMUS [J].