DNA polymerases lose their grip

被引：10

作者：

Beard, WA ^{[1
]}

Wilson, SH ^{[1
]}

机构：

[1] NIH, Natl Inst Environm Hlth Sci, Lab Struct Biol, Res Triangle Pk, NC 27709 USA

来源：

NATURE STRUCTURAL BIOLOGY | 2001年 / 8卷 / 11期

关键词：

D O I：

10.1038/nsb1101-915

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Structural characterization of a variety of DNA polymerases has likened the polymerase domain to a hand that grasps DNA with functional subdomains referred to as fingers, palm and thumb. The solution structure of the African swine fever virus DNA polymerase X indicates that it does not have a hand-like architecture and suggests a mechanism by which the polymerase may compensate for the lack of a dedicated DNA binding subdomain.

引用

页码：915 / 917

页数：3

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