Synthetic and biological studies on coumarin hydrazone derivatives

The reaction of both of coumarin and 6-nitrocoumarin hydrazones (1,4) with alkyl(aryl)isothiocyanate afforded the corresponding 3-N[alkyl(aryl)thioamido] coumarins 3(a-d) or benzopyrano[2,3-c]pyrazole-3-thione derivatives 6(a-d), respectively, Compounds (3(a-d)) were used as key intermediates for the preparation of benzopyrano-pyridine derivatives (7(a-d) & 10(a)) or benzopyranoazepine derivatives 8(a,c) & 12(a-d) through the reaction with different acyl halides or ethoxymethylenemalononitriles and subsequent cyclization. Biological activity of some new compounds against Gram +ve and Gram -ve were given.