A palladium-catalyzed alkylation/direct arylation synthesis of nitrogen-containing heterocycles

被引：88

作者：

Blaszykowski, Christophe ^{[1
]}

Aktoudianakis, Evangelos ^{[1
]}

Adberico, Dino ^{[1
]}

Bressy, Cyril ^{[1
]}

Hulcoop, David G. ^{[1
]}

Jafarpour, Farnaz ^{[1
]}

Joushaghani, Arash ^{[1
]}

Laleu, Benoit ^{[1
]}

Lautens, Mark ^{[1
]}

机构：

[1] Univ Toronto, Dept Chem, Davenport Res Labs, Toronto, ON M5S 3H6, Canada

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 73卷 / 05期

关键词：

D O I：

10.1021/jo702052b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[Graphics] A norbornene-mediated palladium-catalyzed sequence is described in which an alkyl-aryl bond and an aryl-heteroaryl bond are formed in one reaction vessel. The aryl-heteroaryl bond-forming step occurs via a direct arylation reaction. A number of six-, seven-, and eight-membered ring-annulated indoles, pyrroles, pyrazoles, and azaindoles were synthesized from the corresponding bromoalkyl azole and an aryl iodide.

引用

页码：1888 / 1897

页数：10

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