HPLC enantioseparation and absolute configuration of novel anti-inflammatory pyrrole derivatives

被引：12

作者：

Biava, Mariangela ^{[2
]}

Cirilli, Roberto ^{[1
]}

Fares, Vincenzo ^{[3
]}

Ferretti, Rosella ^{[1
]}

Gallinella, Bruno ^{[1
]}

La Torre, Francesco ^{[1
]}

Poce, Giovanna ^{[2
]}

Porretta, Giulio Cesare ^{[2
]}

Supino, Sibilla ^{[2
]}

Villani, Claudio ^{[2
]}

机构：

[1] Ist Super Sanita, Dipartimento Farmaco, I-00161 Rome, Italy

[2] Univ Roma La Sapienza, Dipartimento Studi Chim & Tecnol Sostanze Biologi, I-00185 Rome, Italy

[3] CNR, Ist Cristallog, Sez Monterotondo, I-00016 Monterotondo, Italy

来源：

CHIRALITY | 2008年 / 20卷 / 06期

关键词：

anti-inflammatory pyrrole derivatives; stereoselective HPLC; polysaccharide-based; chiral stationary phases; Chiralpak IA; semipreparative scale enantioseparation; chiroptical properties; absolute configuration;

D O I：

10.1002/chir.20518

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

The assignment of the absolute configuration of novel anti-inflammatory pyrrole derivatives has been accomplished by a combined strategy based on independent physical methods. The key step of our stereochemical characterization approach is the production at mg-scale of enantiomerically pure forms by HPLC on Chiralpak IA stationary phase.

引用

页码：775 / 780

页数：6

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