MicroRNAs: Small regulators with a big impact

被引：54

作者：

Yang, MC ^{[1
]}

Li, Y ^{[1
]}

Padgett, RW ^{[1
]}

机构：

[1] Rutgers State Univ, Canc Inst New Jersey, Dept Mol Biol & Biochem, Waksman Inst, Piscataway, NJ 08854 USA

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2005年 / 16卷 / 4-5期

关键词：

microRNA; RNA; gene regulation; development;

D O I：

10.1016/j.cytogfr.2005.02.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs (miRNA) are non-coding small (similar to 22 nt) RNAs that regulate diverse physiological and developmental processes. In animals, they regulate target genes by binding imperfectly to 3'UTR sequences in mRNAs and attenuate translation. There are hundreds of miRNA genes in animals, and current studies show they constitute a minimum of 1% of known genes. We are just beginning to understand the diverse roles they play in cellular processes, which include signaling pathways, developmental pathways, and possibly various types of cancers. (C) 2005 Elsevier Ltd. All rights reserved.

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收藏

页码：387 / 393

页数：7

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