Improved diagnostics of cerebral gliomas using FET PET

被引：12

作者：

Langen, Karl-Josef ^{[1
,4
]}

Floeth, Frank W. ^{[2
]}

Stoffels, Gabriele ^{[1
,4
]}

Hamacher, Kurt ^{[3
,4
]}

Coenen, Heinz H. ^{[3
,4
]}

Pauleit, Dirk ^{[1
,4
]}

机构：

[1] Forschungszentrum Julich, Med Abt, Inst Neurowissensch & Biophys, D-52425 Julich, Germany

[2] Univ Klinikum Dusseldorf, Neurochirurg Klin, Dusseldorf, Germany

[3] Forschungszentrum Julich, Abt Nukl Chem, Inst Neurowissensch & Biophys, D-52425 Julich, Germany

[4] Forschungszentrum Julich, Brain Imaging Ctr West, D-52425 Julich, Germany

来源：

ZEITSCHRIFT FUR MEDIZINISCHE PHYSIK | 2007年 / 17卷 / 04期

关键词：

amino acid PET; brain tumors; O-(2-[(18)F]fluorethyl)-l-tyrosine (FET);

D O I：

10.1016/j.zemedi.2006.08.001

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Positron emission tomography (PET) using radiolabeled amino acids has shown great potential for more accurate diagnostics of cerebral gliomas. O-(2[(18)F]Fluoroethyl)-L-tyrosine (FET) is a new tracer for PET which can be produced with high efficiency and distributed on a wide clinical scale in Germany. In a biopsy-controlled study, a significant improvement of the detection of true tumor extent of cerebral gliomas could be demonstrated by the combined use of FET PET and MRT in comparison with MRT alone. Advantages of FET PET are an improved guidance of biopsies, an improved planning of surgery and radiation therapy, and the differentiation of tumor recurrence from unspecific post-therapeutic tissue changes. Furthermore, FET PET appears to be particularly valuable in the prognosis of low-grade gliomas.

引用

页码：237 / 241

页数：5

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