Distribution of latent herpes simplex virus type-1 and varicella zoster virus DNA in human trigeminal ganglia

被引：22

作者：

Cohrs, RJ

Laguardia, JJ

Gilden, D

机构：

[1] Univ Colorado, Hlth Sci Ctr, Dept Neurol, Denver, CO 80262 USA

[2] Univ Colorado, Hlth Sci Ctr, Dept Microbiol, Denver, CO 80262 USA

[3] So Illinois Univ, Sch Med, Dept Neurol, Springfield, IL 62794 USA

来源：

VIRUS GENES | 2005年 / 31卷 / 02期

关键词：

distribution; human; herpes simplex virus-1; PCR; trigeminal ganglia; varicella zoster virus;

D O I：

10.1007/s11262-005-1799-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Trigeminal ganglia removed at autopsy from immunocompetent individuals without cutaneous signs of herpesvirus infection were fixed, cut into 5-mu m sections, and screened at 100-mu m intervals ( 20 adjacent sections) by PCR for latent herpes simplex type 1(HSV-1) and varicella zoster virus (VZV) DNA. Sections that contained > 5 neurons with nuclei stained by hematoxylin/eosin revealed HSV-1 DNA in most samples and VZV DNA in approximately 50% of samples. HSV-1 and VZV DNA were distributed throughout each latently infected ganglion.

引用

页码：223 / 227

页数：5

共 18 条

[11]

LaGuardia JJ, 2000, NEUROL RES, V22, P565

[12] Prevalence of varicella-zoster virus DNA in dissociated human trigeminal ganglion neurons and nonneuronal cells [J].