Single-cell transcriptional profiles and spatial patterning of the mammalian olfactory epithelium

被引：23

作者：

Tietjen, I

Rihel, J

Dulac, CG ^{[1
]}

机构：

[1] Harvard Univ, Howard Hughes Med Inst, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

[2] Harvard Univ, Inst Med, Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA 02115 USA

来源：

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY | 2005年 / 49卷 / 2-3期

关键词：

olfactory; development; microarray; single cell;

D O I：

10.1387/ijdb.041939it

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In order to gain insights into the regulatory control of neuronal diversity in the mammalian olfactory system, we have identified the transcriptional profile of individual olfactory neurons. A single cell microarray strategy was performed to search for candidate genes involved in the molecular specification of dorso-ventral zones of olfactory receptor (OR) expression. Several transcripts were identified that display differential expression in distinct OR zones, including a novel family of genes, the Lozenge-like (LzI) genes which share sequence consensus motifs with Lozenge, a transcription factor involved in the patterning of the Drosophila olfactory and visual systems.

引用

页码：201 / 207

页数：7

共 22 条

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