Molecular basis of mechanical modulation of endothelial cell migration

被引:48
作者
Chien, S [1 ]
Li, S
Shiu, YT
Li, YS
机构
[1] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Whitaker Inst Biomed Engn, La Jolla, CA 92093 USA
[3] Univ Calif Berkeley, Dept Biomed Engn, Berkeley, CA 94720 USA
[4] Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA
来源
FRONTIERS IN BIOSCIENCE-LANDMARK | 2005年 / 10卷
关键词
shear stress; endothelial cells; migration; integrins; extracellular matrix; mechanotransduction; cytoskeleton; FAK; Rho; review;
D O I
10.2741/1673
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Vascular endothelial cells (ECs) play important roles in the regulation of vascular functions. Loss of endothelial integrity can lead to vascular diseases such as stenosis resulting from atherosclerosis. The migration of ECs into wounded area in the vessel wall is required for the restoration of its integrity and functions. EC migration results from a balance of externally applied forces (e.g. shear stress), intracellular forces (e.g., those generated by contractile and cytoskeletal proteins), adhesion force between ECs and extracellular matrix (ECM) proteins, and the force of EC-EC coupling through junction proteins. Shear stress modulates EC migration through the regulation of multiple signaling pathways, gene expression, and the reorganization of cytoskeleton, focal adhesion sites, and cell junctions. Investigations of EC migration under shearing can provide valuable knowledge on vascular remodeling process under physiological and pathological conditions.
引用
收藏
页码:1985 / 2000
页数:16
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