Three down and counting: the transformation of human mammary cells from normal to malignant in three steps

被引：1

作者：

Barcellos-Hoff, MH ^{[1
]}

机构：

[1] Lawrence Berkeley Natl Lab, Div Life Sci, Berkeley, CA 94720 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2001年 / 7卷 / 04期

关键词：

D O I：

10.1016/S1471-4914(01)01984-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An array of genetic mutations associated with human breast cancers has been identified, However, which specific combination of mutations permit normal cells to form breast cancer remains unknown. Elenbaas et al. recently described an experimental system for studying the genetic requirements for the development of breast cancer.

引用

页码：142 / 143

页数：2

共 10 条

[1]

Barcellos-Hoff MH, 2000, CANCER RES, V60, P1254

[2]

BISSELL MJ, 1987, J CELL SCI, P327

[3] Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells [J].

Elenbaas, B ;

Spirio, L ;

Koerner, F ;

Fleming, MD ;

Zimonjic, DB ;

Donaher, JL ;

Popescu, NC ;

Hahn, WC ;

Weinberg, RA .

GENES & DEVELOPMENT, 2001, 15 (01) :50-65

[4] Stem cells: A new lease on life [J].

Fuchs, E ;

Segre, JA .

CELL, 2000, 100 (01) :143-155

[5] Creation of human tumour cells with defined genetic elements [J].

Hahn, WC ;

Counter, CM ;

Lundberg, AS ;

Beijersbergen, RL ;

Brooks, MW ;

Weinberg, RA .

NATURE, 1999, 400 (6743) :464-468

[6] The hallmarks of cancer [J].

Hanahan, D ;

Weinberg, RA .

CELL, 2000, 100 (01) :57-70

[7] Landscaping the cancer terrain [J].

Kinzler, KW ;

Vogelstein, B .

SCIENCE, 1998, 280 (5366) :1036-1037

[8] Cancer-susceptibility genes - Gatekeepers and caretakers [J].

Kinzler, KW ;

Vogelstein, B .

NATURE, 1997, 386 (6627) :761-&

[9] Human cancer cell lines: fact and fantasy [J].

Masters, JRW .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2000, 1 (03) :233-236

[10] The influence of the microenvironment on the malignant phenotype [J].

Park, CC ;

Bissell, MJ ;

Barcellos-Hoff, MH .

MOLECULAR MEDICINE TODAY, 2000, 6 (08) :324-329

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