Imidazole and benzimidazole derivatives as chemotherapeutic agents

被引：418

作者：

Boiani, M ^{[1
]}

González, M ^{[1
]}

机构：

[1] Univ Republica, Dept Quim Organ, Fac Ciencias, Fac Quim, Montevideo 11400, Uruguay

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2005年 / 5卷 / 04期

关键词：

D O I：

10.2174/1389557053544047

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Imidazole and benzimidazole systems are presented in a large number of common therapeutics agents. They were widely used in organic and medicinal chemistry, but recently the development of N-oxide derivatives got an improvement from the point of view of its chemical and biological activity. Though we will review recent developments in chemical and biological profiles (as antitumoral, antiparasitic, antiviral and antimicrobial agents) of these heterocycle systems and the corresponding N-oxides.

引用

页码：409 / 424

页数：16

共 137 条

[11] BOIANI M, 2002, DRUGS FUTURE SA, V27, P245
[12] An intramolecular palladium-catalysed aryl amination reaction to produce benzimidazoles
Brain, CT
Brunton, SA
[J]. TETRAHEDRON LETTERS, 2002, 43 (10) : 1893 - 1895
[13] Design, synthesis, and tripeptidyl peptidase II inhibitory activity of a novel series of (S)-2,3-dihydro-2-(4-alkyl-1H-imidazol-2-yl)-1H-indoles
Breslin, HJ
Miskowski, TA
Kukla, MJ
Leister, WH
De Winter, HL
Gauthier, DA
Somers, MVF
Peeters, DCG
Roevens, PWM
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (24) : 5303 - 5310
[14] A study on the antioxidant capacities of some benzimidazoles in rat tissues
Can-Eke, B
Puskullu, MO
Buyukbingol, E
Iscan, M
[J]. CHEMICO-BIOLOGICAL INTERACTIONS, 1998, 113 (01) : 65 - 77
[15] 1,2,5-oxadiazole N-oxide derivatives and related compounds as potential antitrypanosomal drugs:: Structure-activity relationships
Cerecetto, H
Di Maio, R
González, M
Risso, M
Saenz, P
Seoane, G
Denicola, A
Peluffo, G
Quijano, C
Olea-Azar, C
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (11) : 1941 - 1950
[16] Cerecetto Hugo, 2002, Current Topics in Medicinal Chemistry, V2, P1187, DOI 10.2174/1568026023393066
[17] CHAPMAN JD, 1989, INT J RADIAT ONCOL, V16, P911
[18] Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead
Chauvière, G
Bouteille, B
Enanga, B
de Albuquerque, C
Croft, SL
Dumas, M
Périé, J
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (03) : 427 - 440
[19] DNA MINOR GROOVE-BINDING LIGANDS - A DIFFERENT CLASS OF MAMMALIAN DNA TOPOISOMERASE-I INHIBITORS
CHEN, AY
YU, C
GATTO, B
LIU, LF
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (17) : 8131 - 8135
[20] FIRST GENERATION AROMATASE INHIBITORS - AMINOGLUTETHIMIDE AND TESTOLOLACTONE
COCCONI, G
[J]. BREAST CANCER RESEARCH AND TREATMENT, 1994, 30 (01) : 57 - 80

← 1 2 3 4 5 6 7 8 9 10 →