学术探索
学术期刊
新闻热点
数据分析
智能评审

Imidazole and benzimidazole derivatives as chemotherapeutic agents

被引：418
作者：
Boiani, M [1 ]
González, M [1 ]
机构：
[1] Univ Republica, Dept Quim Organ, Fac Ciencias, Fac Quim, Montevideo 11400, Uruguay
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2005年 / 5卷 / 04期
关键词：
D O I：
10.2174/1389557053544047
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Imidazole and benzimidazole systems are presented in a large number of common therapeutics agents. They were widely used in organic and medicinal chemistry, but recently the development of N-oxide derivatives got an improvement from the point of view of its chemical and biological activity. Though we will review recent developments in chemical and biological profiles (as antitumoral, antiparasitic, antiviral and antimicrobial agents) of these heterocycle systems and the corresponding N-oxides.
引用
收藏
页码：409 / 424
页数：16
相关论文
共 137 条
  • [61] Kamal MR, 1999, HETEROCYCLES, V50, P819
  • [62] Synthesis of some 1-(2-naphthyl)-2-(imidazole-1-yl)ethanone oxime and oxime ether derivatives and their anticonvulsant and antimicrobial activities
    Karakurt, A
    Dalkara, S
    Özalp, M
    Özbey, S
    Kendi, E
    Stables, JP
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2001, 36 (05) : 421 - 433
  • [63] New antimetastatic hypoxic cell radiosensitizers: Design, synthesis, and biological activities of 2-nitroimidazole-acetamide, TX-1877, and its analogues
    Kasai, S
    Nagasawa, H
    Yamashita, M
    Masui, M
    Kuwasaka, H
    Oshodani, T
    Uto, Y
    Inomata, T
    Oka, S
    Inayama, S
    Hori, H
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2001, 9 (02) : 453 - 464
  • [64] Solid-phase synthesis of substituted 2-aminomethylbenzimidazoles
    Kilburn, JP
    Lau, J
    Jones, RCF
    [J]. TETRAHEDRON LETTERS, 2000, 41 (28) : 5419 - 5421
  • [65] Substituted 2,5'-bi-1H-benzimidazoles: Topoisomerase I inhibition and cytotoxicity
    Kim, JS
    Gatto, B
    Yu, C
    Liu, A
    Liu, LF
    LaVoie, EJ
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (04) : 992 - 998
  • [66] Synthesis and preliminary evaluation of benzimidazole derivatives as antimicrobial agents
    Klimesová, V
    Kocí, J
    Pour, M
    Stachel, J
    Waisser, K
    Kaustová, J
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2002, 37 (05) : 409 - 418
  • [67] INTERACTION OF REDUCED METRONIDAZOLE WITH DNA
    KNIGHT, RC
    SKOLIMOWSKI, IM
    EDWARDS, DI
    [J]. BIOCHEMICAL PHARMACOLOGY, 1978, 27 (17) : 2089 - 2093
  • [68] INTERACTION OF NITROIMIDAZOLE DRUGS WITH DNA INVITRO - STRUCTURE-ACTIVITY-RELATIONSHIPS
    KNOX, RJ
    KNIGHT, RC
    EDWARDS, DI
    [J]. BRITISH JOURNAL OF CANCER, 1981, 44 (05) : 741 - 745
  • [69] The biochemical basis of anthelmintic action and resistance
    Köhler, P
    [J]. INTERNATIONAL JOURNAL FOR PARASITOLOGY, 2001, 31 (04) : 336 - 345
  • [70] Structure-activity relationship of 2-[[(2-pyridyl)methyl]thio]-1H-benzimidazoles as anti Helicobacter pylori agents in vitro and evaluation of their in vivo efficacy
    Kühler, TC
    Swanson, M
    Shcherbuchin, V
    Larsson, H
    Mellgard, B
    Sjöström, JE
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (11) : 1777 - 1788
234567891011