A novel G protein-coupled receptor with homology to neuropeptide and chemoattractant receptors expressed during bone development

被引:48
作者
Methner, A [1 ]
Hermey, G [1 ]
Schinke, B [1 ]
HermansBorgmeyer, I [1 ]
机构
[1] UNIV HAMBURG,CTR MOL NEUROBIOL,D-20246 HAMBURG,GERMANY
关键词
D O I
10.1006/bbrc.1997.6455
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A novel G protein-coupled receptor was isolated from a cDNA derived from the cell line NH15-CA2 and a cDNA library from adult mouse brain using a PCR cloning strategy, The amino acid sequence of the candidate receptor DEZ showed homology to neuropeptide and chemoattractant receptors, Highest overall homology was found with the orphan receptor GPR-1 (65%), the angiotensin II receptor (62%), and the C5a anaphylatoxin receptor (60%), Northern blot analysis of dez revealed a predominant 2.6 kb mRNA species in NH15-CA2 cells, In situ hybridization experiments showed that dez is differentially regulated during development, with a prominent expression in developing osseous and cartilaginous tissue, It was also detectable in the adult parathyroid glands, hinting at a possible function in bone metabolism. (C) 1997 Academic Press.
引用
收藏
页码:336 / 342
页数:7
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