Cancer theranostics: the rise of targeted magnetic nanoparticles

被引：311

作者：

Cole, Adam J. ^{[1
]}

Yang, Victor C. ^{[1
,2
,3
]}

David, Allan E. ^{[1
,4
]}

机构：

[1] Univ Michigan, Coll Pharm, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA

[2] Tianjin Med Univ, Sch Pharm, Tianjin 300070, Peoples R China

[3] Tianjin Key Lab Modern Drug Delivery & High Effic, Tianjin 300070, Peoples R China

[4] Ind Sci & Technol Network Inc, York, PA 17404 USA

来源：

TRENDS IN BIOTECHNOLOGY | 2011年 / 29卷 / 07期

基金：

美国国家卫生研究院;

关键词：

IRON-OXIDE NANOPARTICLES; CORE-SHELL NANOPARTICLES; DRUG-DELIVERY; SUPERPARAMAGNETIC NANOPARTICLES; THERAPY; BIODISTRIBUTION; CELLS; AGENTS; TUMORS;

D O I：

10.1016/j.tibtech.2011.03.001

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Interest in utilizing magnetic nanoparticles (MNP) for biomedical applications has increased considerably over the past two decades. This excitement has been driven in large part by the success of MNPs as contrast agents in magnetic resonance imaging. The recent investigative trend with respect to cancer has continued down a diagnostic path, but has also turned toward concurrent therapy, giving rise to the distinction of MNPs as potential "theranostics". Here we review both the key technical principles of MNPs and ongoing advancement toward a cancer theranostic MNP. Recent progress in diagnostics, hyperthermia treatments, and drug delivery are all considered. We conclude by identifying current barriers to clinical translation of MNPs and offer considerations for their future development.

引用

页码：323 / 332

页数：10

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