Characterization of solid counterfeit drug samples by desorption electrospray ionization and direct-analysis-in-real-time coupled to time-of-flight mass spectrometry

被引：168

作者：

Fernandez, Facundo M.

Cody, Robert B.

Green, Michael D.

Hampton, Christina Y.

McGready, Rose

Sengaloundeth, Sivong

White, Nicholas J.

Newton, Paul N.

机构：

[1] School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332

[2] JEOL USA, Inc., Peabody, MA 01960

[3] Division of Parasitic Diseases, National Center for Infectious Diseases, Center for Disease Control and Prevention, Atlanta, GA 30333

[4] Shoklo Malaria Research Unit, Mae Sot, Tak

[5] Food and Drug Department, Ministry of Health, Government of the Lao PDR, Vientiane

[6] Microbiology Laboratory, Mahosot Hospital, Wellcome Trust-Mahosot Hospital-Oxford Tropical Medicine Research Collaboration, Vientiane

[7] Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford University, Oxford

[8] Wellcome Trust-Mahidol University-Oxford Tropical Medicine Research Programme, Faculty of Tropical Medicine, Mahidol University, Bangkok

来源：

CHEMMEDCHEM | 2006年 / 1卷 / 07期

基金：

英国惠康基金;

关键词：

Analytical methods; DART; DESI; Mass spectrometry; Medicinal chemistry;

D O I：

10.1002/cmdc.200600041

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Vacuum is not the limit: direct analysis in real time (DART), a new MS ionization method, allows probing of pharmaceuticals under atmospheric pressure, thus bypassing lengthy sample preparation steps and enhancing throughput. DART allows rapid screening of solid drugs at almost constant temperature which decreases errors in mass measurement and improves the identification of potentially harmful unknowns. This is important for identifying counterfeit drugs (fake hologram shown).

引用

页码：702 / +

页数：5

共 31 条

[11] Analytical performance of a venturi device integrated into an electrospray ionization Fourier transform ion cyclotron resonance mass spectrometer for analysis of nucleic acids [J].