Solvent-free cycloaddition reaction of 3-indolylimines with chloroacetyl chloride under microwave irradiation

被引：11

作者：

Dandia, A ^{[1
]}

Singh, R ^{[1
]}

Sharma, P ^{[1
]}

机构：

[1] Univ Rajasthan, Dept Chem, Jaipur 302004, Rajasthan, India

来源：

HETEROATOM CHEMISTRY | 2003年 / 14卷 / 05期

关键词：

D O I：

10.1002/hc.10180

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Solvent-free approach is developed fior the rapid synthesis of spiro[azetidine-indoles] 6a-g on basic alumina supported potassium carbonate (K2CO3-Al2O3) from the cycloaddition reaction of indolylimines 3 and chloroacetyl chloride 4 as synthons using microwaves. The procedure neither required toxic and hazardous base nor volatile solvents. 3 was synthesized in situ by the neat reaction of indole-2,3-diones I and fluorinated anilines 2 under microwave irradiation. Solvent-free aminoalkylation of spiro compounds 6a and 6b has been carried out under microwaves. (C) 2003 Wiley Periodicals, Inc.

引用

页码：468 / 473

页数：6

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