Chiral counteranions in asymmetric transition-metal catalysis:: Highly enantioselective Pd/Bronsted acid-catalyzed direct α-allylation of aldehydes

被引：520

作者：

Mukherjee, Santanu ^{[1
]}

List, Benjamin ^{[1
]}

机构：

[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 37期

关键词：

D O I：

10.1021/ja074678r

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have developed a highly enantioselective Pd/chiral acid-catalyzed alpha-allylation of alpha-branched aldehydes with an allyl amine as the allylating species that creates all-carbon quaternary stereogenic centers in high yields and enantioselectivities. To our knowledge, this is the first time that a chiral anionic ligand is applied for achieving asymmetric induction in a palladium-catalyzed allylic alkylation reaction.

引用

页码：11336 / +

页数：3

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