T cell immunity in hepatitis B and hepatitis C virus infection: implications for autoimmunity

被引：28

作者：

Ichiki, Y

He, XS

Shimoda, S

Ishibashi, H

Keeffe, EB

Rossaro, L

Gershwin, ME

机构：

[1] Univ Calif Davis, Sch Med, Div Rheumatol Allergy & Clin Immunol, Davis, CA 95616 USA

[2] Kyushu Univ, Grad Sch Med Sci, Higashi Ku, Fukuoka 8128582, Japan

[3] Nagasaki Med Ctr, Clin Res Ctr, Nagasaki 8568562, Japan

[4] Stanford Univ, Med Ctr, Dept Med, Div Gastroenterol & Hepatol, Palo Alto, CA 94304 USA

[5] Univ Calif Davis, Transplant Med Housestaff FAC, Sacramento, CA 95817 USA

来源：

AUTOIMMUNITY REVIEWS | 2005年 / 4卷 / 02期

关键词：

D O I：

10.1016/j.autrev.2004.12.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T cells are involved in the pathogenesis of important liver diseases including both autoimmune liver diseases, and viral hepatitis. In addition to playing a crucial role in the control of hepatitis viruses, T cell responses are also responsible for the liver injury during acute and chronic phases of viral hepatitis. In this article, we reviewed current literature on T cell immunity to hepatitis B and C viruses. In addition, antigen presenting cells that are critical for T cell immunity against these viruses are also discussed. This will provide insights to the understanding of T cell immunity in autoimmune liver diseases due to the similar role of T cells in autoimmune liver diseases and viral hepatitis. (c) 2005 Elsevier B.V. All rights reserved.

引用

收藏

页码：82 / 95

页数：14

相关论文

共 88 条

[41] Viral hepatitis B [J].

Lai, CL ;

Ratziu, V ;

Yuen, MF ;

Poynard, T .

LANCET, 2003, 362 (9401) :2089-2094

[42] Conserved hepatitis C virus sequences are highly immunogenic for CD4+ T cells:: Implications for vaccine development [J].

Lamonaca, V ;

Missale, G ;

Urbani, S ;

Pilli, M ;

Boni, C ;

Mori, C ;

Sette, A ;

Massari, M ;

Southwood, S ;

Bertoni, R ;

Valli, A ;

Fiaccadori, F ;

Ferrari, C .

HEPATOLOGY, 1999, 30 (04) :1088-1098

[43] Lack of phenotypic and functional impairment in dendritic cells from chimpanzees chronically infected with hepatitis C virus [J].

Larsson, M ;

Babcock, E ;

Grakoui, A ;

Shoukry, N ;

Lauer, G ;

Rice, C ;

Walker, C ;

Bhardwaj, N .

JOURNAL OF VIROLOGY, 2004, 78 (12) :6151-6161

[44]

Lechner F, 2000, EUR J IMMUNOL, V30, P2479, DOI 10.1002/1521-4141(200009)30:9<2479::AID-IMMU2479>3.0.CO

[45]

2-B

[46] Analysis of successful immune responses in persons infected with hepatitis C virus [J].

Lechner, F ;

Wong, DKH ;

Dunbar, PR ;

Chapman, R ;

Chung, RT ;

Dohrenwend, P ;

Robbins, G ;

Phillips, R ;

Klenerman, P ;

Walker, BD .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (09) :1499-1512

[47] Phenotypic and functional characterization of intrahepatic T lymphocytes during chronic hepatitis C [J].

Leroy, V ;

Vigan, I ;

Mosnier, JF ;

Dufeu-Duchesne, T ;

Pernollet, M ;

Zarski, JP ;

Marche, PN ;

Jouvin-Marche, E .

HEPATOLOGY, 2003, 38 (04) :829-841

[48]

Löhr HF, 1998, LIVER, V18, P405

[49] Reduced virus specific T helper cell induction by autologous dendritic cells in patients with chronic hepatitis B -: restoration by exogenous interleukin-12 [J].

Löhr, HF ;

Pingel, S ;

Böchner, WO ;

Bernhard, H ;

Herzog-Hauff, S ;

Rose-John, S ;

Galle, PR .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2002, 130 (01) :107-114

[50] PROLIFERATIVE RESPONSE OF CD4(+) T-CELLS AND HEPATITIS-B VIRUS CLEARANCE IN CHRONIC HEPATITIS WITH OR WITHOUT HEPATITIS-B E-MINUS HEPATITIS-B VIRUS MUTANTS [J].

LOHR, HF ;

WEBER, W ;

SCHLAAK, J ;

GOERGEN, B ;

ZUMBUSCHENFELDE, KHM ;

GERKEN, G .

HEPATOLOGY, 1995, 22 (01) :61-68

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