T cell immunity in hepatitis B and hepatitis C virus infection: implications for autoimmunity

被引：28

作者：

Ichiki, Y

He, XS

Shimoda, S

Ishibashi, H

Keeffe, EB

Rossaro, L

Gershwin, ME

机构：

[1] Univ Calif Davis, Sch Med, Div Rheumatol Allergy & Clin Immunol, Davis, CA 95616 USA

[2] Kyushu Univ, Grad Sch Med Sci, Higashi Ku, Fukuoka 8128582, Japan

[3] Nagasaki Med Ctr, Clin Res Ctr, Nagasaki 8568562, Japan

[4] Stanford Univ, Med Ctr, Dept Med, Div Gastroenterol & Hepatol, Palo Alto, CA 94304 USA

[5] Univ Calif Davis, Transplant Med Housestaff FAC, Sacramento, CA 95817 USA

来源：

AUTOIMMUNITY REVIEWS | 2005年 / 4卷 / 02期

关键词：

D O I：

10.1016/j.autrev.2004.12.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T cells are involved in the pathogenesis of important liver diseases including both autoimmune liver diseases, and viral hepatitis. In addition to playing a crucial role in the control of hepatitis viruses, T cell responses are also responsible for the liver injury during acute and chronic phases of viral hepatitis. In this article, we reviewed current literature on T cell immunity to hepatitis B and C viruses. In addition, antigen presenting cells that are critical for T cell immunity against these viruses are also discussed. This will provide insights to the understanding of T cell immunity in autoimmune liver diseases due to the similar role of T cells in autoimmune liver diseases and viral hepatitis. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：82 / 95

页数：14

共 88 条

[81] Detection of functionally altered hepatitis C virus-specific CD4+ T cells in acute and chronic hepatitis C [J].