Structure-based design of protein tyrosine phosphatase-1B inhibitors

被引：69

作者：

Black, E

Breed, J

Breeze, AL

Embrey, K

Garcia, R

Gero, TW

Godfrey, L

Kenny, PW

Morley, AD

Minshull, CA

Pannifer, AD

Read, J

Rees, A

Russell, DJ

Toader, D

Tucker, J

机构：

[1] AstraZeneca, Macclesfield SK10 4TG, Cheshire, England

[2] AstraZeneca, Waltham, MA 02451 USA

[3] Pfizer Ltd, Cent Res, Sandwich CT13 9NJ, Kent, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 10期

关键词：

protein tyrosine phosphatase-1B; structure-based design;

D O I：

10.1016/j.bmcl.2005.03.068

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Using structure-based design, a new class of inhibitors of protein tyrosine phosphatase-1B (PTP1B) has been identified, which incorporate the 1,2,5-thiadiazolidin-3-one-1, 1-dioxide template. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2503 / 2507

页数：5

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