Drug-induced stabilisation of a mismatched C-T base pair in a DNA hairpin

被引:8
作者
Gallagher, CT [1 ]
Searle, MS [1 ]
机构
[1] Sch Chem, Nottingham NG7 2RD, England
关键词
D O I
10.1039/b305337g
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
We have shown that a key feature of drug binding, namely specific G-C base pair recognition at a 5A-TG step, can induce a number of novel structural features when an extrahelical base is inserted in close proximity to the drug binding site; we have clearly demonstrated the formation of a stabilised C-T mismatched base pair at a non-terminal site.
引用
收藏
页码:1814 / 1815
页数:2
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共 20 条
[1]   IMPROVED BACTERIAL TEST SYSTEM FOR DETECTION AND CLASSIFICATION OF MUTAGENS AND CARCINOGENS [J].
AMES, BN ;
LEE, FD ;
DURSTON, WE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1973, 70 (03) :782-786
[2]   Binding of the antitumor drug nogalamycin to bulged DNA structures [J].
CaceresCortes, J ;
Wang, AHJ .
BIOCHEMISTRY, 1996, 35 (02) :616-625
[3]   Structure of a drug-induced DNA T-bulge: Implications for DNA frameshift mutations [J].
Colgrave, ML ;
Williams, HEL ;
Searle, MS .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2002, 41 (24) :4754-4756
[4]   MOST COMPACT HAIRPIN-TURN STRUCTURE EXERTED BY A SHORT DNA FRAGMENT, D(GCGAAGC) IN SOLUTION - AN EXTRAORDINARILY STABLE STRUCTURE RESISTANT TO NUCLEASES AND HEAT [J].
HIRAO, I ;
KAWAI, G ;
YOSHIZAWA, S ;
NISHIMURA, Y ;
ISHIDO, Y ;
WATANABE, K ;
MIURA, K .
NUCLEIC ACIDS RESEARCH, 1994, 22 (04) :576-582
[5]   CONFORMATIONAL TRANSITIONS IN CYTIDINE BULGE-CONTAINING DEOXYTRIDECANUCLEOTIDE DUPLEXES - EXTRA CYTIDINE EQUILIBRATES BETWEEN LOOPED OUT (LOW-TEMPERATURE) AND STACKED (ELEVATED-TEMPERATURE) CONFORMATIONS IN SOLUTION [J].
KALNIK, MW ;
NORMAN, DG ;
ZAGORSKI, MG ;
SWANN, PF ;
PATEL, DJ .
BIOCHEMISTRY, 1989, 28 (01) :294-303
[6]   Characterization of a covalent monoadduct of neocarzinostatin chromophore at a DNA bulge [J].
Kappen, LS ;
Goldberg, IH .
BIOCHEMISTRY, 1997, 36 (48) :14861-14867
[7]   MOLMOL: A program for display and analysis of macromolecular structures [J].
Koradi, R ;
Billeter, M ;
Wuthrich, K .
JOURNAL OF MOLECULAR GRAPHICS, 1996, 14 (01) :51-&
[8]   Interaction of DNA polymerase I (Klenow fragment) with DNA substrates containing extrahelical bases: Implications for proofreading of frameshift errors during DNA synthesis [J].
Lam, WC ;
Van der Schans, EJC ;
Sowers, LC ;
Millar, DP .
BIOCHEMISTRY, 1999, 38 (09) :2661-2668
[9]   Photocross-linking of the NH2-terminal region of Taq MutS protein to the major groove of a heteroduplex DNA [J].
Malkov, VA ;
Biswas, I ;
CameriniOtero, RD ;
Hsieh, P .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (38) :23811-23817
[10]   Recognition of a single guanine bulge by 2-acylamino-1,8-naphthyridine [J].
Nakatani, K ;
Sando, S ;
Saito, I .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (10) :2172-2177