Serologic responses of 42 MERS-coronavirus-infected patients according to the disease severity

被引：65

作者：

Ko, Jae-Hoon ^{[1
,10
]}

Mueller, Marcel A. ^{[2
,3
]}

Seok, Hyeri ^{[1
]}

Park, Ga Eun ^{[1
]}

Lee, Ji Yeon ^{[1
]}

Cho, Sun Young ^{[1
]}

Ha, Young Eun ^{[1
]}

Baek, Jin Yang ^{[4
]}

Kim, So Hyun ^{[4
]}

Kang, Ji-Man ^{[5
]}

Kim, Yae-Jean ^{[5
]}

Jo, Lk Joon ^{[6
]}

Chung, Chi Ryang ^{[7
]}

Hahn, Myong-Joon ^{[8
]}

Drosten, Christian ^{[2
,3
]}

Kang, Cheol-In ^{[1
]}

Chung, Doo Ryeon ^{[1
,4
]}

Song, Jae-Hoon ^{[1
,4
]}

Kang, Eun-Suk ^{[9
]}

Peck, Kyong Ran ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Infect Dis,Dept Med, 81 Irwon Ro, Seoul 06351, South Korea

[2] Charite, Inst Virol, Berlin, Germany

[3] German Ctr Infect Res, Braunschweig, Germany

[4] APFID, Seoul, South Korea

[5] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Infect Dis,Dept Pediat, Seoul, South Korea

[6] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Emergency Med, Seoul, South Korea

[7] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Crit Care Med, Seoul, South Korea

[8] Sungkyunkwan Univ, Sch Med, Samsung Biomed Res Inst, Dept Mol Cell Biol,Ctr Mol Med, Suwon 16419, South Korea

[9] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Lab Med & Genet, Seoul, South Korea

[10] Armed Forces Capital Hosp, Dept Internal Med, Div Infect Dis, Seongnam, South Korea

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2017年 / 89卷 / 02期

关键词：

Middle East respiratory syndrome coronavirus; Prognosis; Antibody; Serologic response; EAST RESPIRATORY SYNDROME; ANTIBODIES; PNEUMONIA; OUTBREAK;

D O I：

10.1016/j.diagmicrobio.2017.07.006

中图分类号：

R51 [传染病];

学科分类号：

100201 [内科学];

摘要：

We evaluated serologic response of 42 Middle East respiratory syndrome coronavirus (MERS-CoV)-infected patients according to 4 severity groups: asymptomatic infection (Group 0), symptomatic infection without pneumonia (Group 1), pneumonia without respiratory failure (Group 2), and pneumonia progressing to respiratory failure (Group 3). None of the Group 0 patients showed seroconversion, while the seroconversion rate gradually increased with increasing disease severity (0.0%, 60.0%, 93.8%, and 100% in Group 0, 1, 2, 3, respectively; P = 0.001), Group 3 patients showed delayed increment of antibody titers during the fourth week, while Group 2 patients showed robust increment of antibody titer during the third week. Among patients having pneumonia, 75% of deceased patients did not show seroconversion by the third week, while 100% of the survived patients were seroconverted (P = 0.003). (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：106 / 111

页数：6

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